Jump to content
We’re excited to announce the forum is under new management! Details to follow.

Coronavirus - Part Two.

Recommended Posts

1 hour ago, petemcewan said:

Tinfoilha t,

Thanks for that uplifting news. The results do look promising.

I'd just like to add something.

If it was me participating in the trail, I wouldn't be very happy if I found I'd been given  a placebo. A historical note.In the early days of the HIV pandemic.The organisation Act Up campaigned against placebos being used in the search to find a treatment for HIV.

I think their slogan was" drugs into bodies".

 

https://www.theatlantic.com/health/archive/2011/12/the-placebo-debate-is-it-unethical-to-prescribe-them-to-patients/250161/

That's ridiculous. The placebo is needed to provide a comparison between people with the drug and ones without during a clinical trial.

Share this post


Link to post
Share on other sites
Posted (edited)
5 minutes ago, the_bloke said:

That's ridiculous. The placebo is needed to provide a comparison between people with the drug and ones without during a clinical trial.

Exactly.  In some trials the placebo is administered with existing treatments.

Edited by Arnold_Lane

Share this post


Link to post
Share on other sites
Posted (edited)

I see so many with their nose not covered by their masks. Some just don't understand how breathing and viruses work sigh

Edited by melthebell

Share this post


Link to post
Share on other sites
1 hour ago, melthebell said:

I see so many with their nose not covered by their masks. Some just don't understand how breathing and viruses work sigh

Perhaps it's time to bring back the slogan "coughs and sneezes spread diseases".

Share this post


Link to post
Share on other sites
44 minutes ago, Longcol said:

Perhaps it's time to bring back the slogan "coughs and sneezes spread diseases".

Or maybe "Are you only wearing your mask over your mouth? You are a moron. Don't be a moron and wear you mask properly".

 

It's not hard is it.

Share this post


Link to post
Share on other sites
Posted (edited)
5 hours ago, tinfoilhat said:

Or maybe "Are you only wearing your mask over your mouth? You are a moron. Don't be a moron and wear you mask properly".

 

It's not hard is it.

Anyone not wearing it properly deserves it as far as I'm concerned. I'm looking forward to the day we see someone wearing it only over their mouth scalding someone in public for not wearing one at all. 

 

I'm seeing very little about the good news on the BBC regarding a potential vaccine triggering an immune response. A quote on the BBC says the trial has been expanded to other countries as the virus levels in the UK are low. Whilst it isn't guaranteed it's a possibility if everything works out well that a vaccine could be developed by the end of the year. An unbelievable accomplishment if it manages to happen. 

Edited by Tomm06

Share this post


Link to post
Share on other sites

Dump the placebo arm of Covid -19 vaccine trials. Get on with Challenge Vaccination Trials. And well have a vaccine before 2021.

Share this post


Link to post
Share on other sites
34 minutes ago, petemcewan said:

Dump the placebo arm of Covid -19 vaccine trials.

Lets not thank you, placebos are there to determine genuine side effects, I don't want to take a rushed through vaccine and then find out it causes dementia or something because it wasn't done properly. Patience is a virtue.   

Share this post


Link to post
Share on other sites
Posted (edited)

Dardedec,

I'm not looking for any thank you.

There are different approaches to clinical trials .

If you care to read the link -I've provided -you will be able to see the context  for what I've written.

Using  a "Historical Control Group" approach can get round having to use placebos.

I'm not advocating compromising safety ,but a means of speeding up the whole process.

The quicker we get to safe and effective treatments and vaccines the more lives will be saved.

 

Note: Historical Control Group is explained in the link.

 

https://www.theguardian.com/science/2013/dec/01/world-aids-day-how-aids-activists-changed-medical-research

 

 

Edited by petemcewan

Share this post


Link to post
Share on other sites
32 minutes ago, petemcewan said:

Dardedec,

I'm not looking for any thank you.

There are different approaches to clinical trials .

If you care to read the link -I've provided -you will be able to see the context  for what I've written.

Using  a "Historical Control Group" approach can get round having to use placebos.

I'm not advocating compromising safety ,but a means of speeding up the whole process.

The quicker we get to safe and effective treatments and vaccines the more lives will be saved.

 

Note: Historical Control Group is explained in the link.

 

https://www.theguardian.com/science/2013/dec/01/world-aids-day-how-aids-activists-changed-medical-research

 

 

True enough.  Why do you think experts in this field have chosen the placebo route when they could have used a Historical Control Group that a guy on Sheffield Forum with no relevant qualifications says is better?

Share this post


Link to post
Share on other sites
3 hours ago, petemcewan said:

Dardedec,

I'm not looking for any thank you.

There are different approaches to clinical trials .

If you care to read the link -I've provided -you will be able to see the context  for what I've written.

Using  a "Historical Control Group" approach can get round having to use placebos.

I'm not advocating compromising safety ,but a means of speeding up the whole process.

The quicker we get to safe and effective treatments and vaccines the more lives will be saved.

 

Note: Historical Control Group is explained in the link.

 

https://www.theguardian.com/science/2013/dec/01/world-aids-day-how-aids-activists-changed-medical-research

 

 

How do we have a Historical Control Group of enough depth to provide a comparison without any doubt in a trial of a brand new drug that has only just started development?

 

You can't. The data doesn't exist for those administering the trial to know that patient N who weighs X, is Y years old and has ABCDE and F underlying health conditions will react in the test conditions compared to someone being given the drug. You need thousands of people to get this data from previous clinical trials with placebos.

Share this post


Link to post
Share on other sites

Well, I don't know about all that folks, but I would like to see the figures from new infections in Leeds and Liverpool in around a fortnight.  Both football teams are having celebrations (again) and telling fans not to go to the respective stadiums.  Hasn't stopped them before, has it?  Expect the evening news to have footage of thousands of fans again NOT social distancing, NOT wearing masks, and NOT being arrested as there are simply too many of them for the police to handle.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.