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petemcewan

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  1. Arnold Lane, I hope the following answers some of your questions. It's only a small trial .But it contains good news. Right at the end is reference to Historical Group control. I can only guess at an answer to your question about the 30yr. old. There may be some problems with that person's immune system like low levels of CD4, CD8 cells, that predisposes a person to getting a severe infection. The Randomised Placebo Control Trial is the gold standard. But it's not the only way of doing trials. I'm biased towards the no placebo approach because people get active treatment . https://www.pnas.org/content/117/17/9490
  2. Arnold Lane, No need for any apology. Your question is a good one and not aggressive at all. I don't pretend to be an expert . I was part of Act Up back in the day, and lobbied the pharmaceutical /research industry to get some giddy up with their research into Antiretrovirals for the treatment of HIV. The following link explains- better than I can- the advantages of Historica Control Groups over Placebo Controls. https://www.statisticshowto.com/historical-controls/
  3. The bloke, With respect. It explains itself. The medical records are available-giving the required data that is necessary for conducting the trial.Epidemiologist and researchers are well aware of "Historical Control" procedures. Adopting the procedure gets them out of unethical problems, that obtain in placebo conducted trials. "A control group that is chosen from a group of patients who were observed at some time in the past or for whom data are available through records. Historical controls are used for comparison with subjects being treated or assessed concurrently" Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved. Historical Control Groups are not new, off the wall,quack way of proceeding. historical control " Epidemiology A control group that is chosen from a group of patients who were observed at some time in the past or for whom data are available through records; HCs are used for comparison with subjects being treated concurrently. See Control."
  4. Dardedec, I'm not looking for any thank you. There are different approaches to clinical trials . If you care to read the link -I've provided -you will be able to see the context for what I've written. Using a "Historical Control Group" approach can get round having to use placebos. I'm not advocating compromising safety ,but a means of speeding up the whole process. The quicker we get to safe and effective treatments and vaccines the more lives will be saved. Note: Historical Control Group is explained in the link. https://www.theguardian.com/science/2013/dec/01/world-aids-day-how-aids-activists-changed-medical-research
  5. Dump the placebo arm of Covid -19 vaccine trials. Get on with Challenge Vaccination Trials. And well have a vaccine before 2021.
  6. Tinfoilha t, Thanks for that uplifting news. The results do look promising. I'd just like to add something. If it was me participating in the trail, I wouldn't be very happy if I found I'd been given a placebo. A historical note.In the early days of the HIV pandemic.The organisation Act Up campaigned against placebos being used in the search to find a treatment for HIV. I think their slogan was" drugs into bodies". https://www.theatlantic.com/health/archive/2011/12/the-placebo-debate-is-it-unethical-to-prescribe-them-to-patients/250161/
  7. I heard yesterday on the radio that "Challenge Vaccination Trials" for Covid-19 are being considered. Such a programme can speed up the introduction of a safe and effective vaccine. https://www.fredhutch.org/en/news/center-news/2020/06/covid-vaccine-challenge-trials.html Vaccine front runners https://www.the-scientist.com/news-opinion/covid-19-vaccine-frontrunners-67382?utm_campaign=TS_DAILY NEWSLETTER_2020&utm_medium=email&_hs
  8. On a day like today this makes my blood run young again. https://www.youtube.com/watch?v=oEHBTjIYejE
  9. Some of the best tunes and lyrics ever written.
  10. Such sweet music from Gerry Mulligan.
  11. https://www.youtube.com/watch?v=LlYRNBXygUc
  12. may you all be protected during this pandemic. https://www.youtube.com/watch?v=6eb_9lG1fNY
  13. I'll play this on my valve trombone at 2000hrs on Thursday for all those NHS workers. God bless them.
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